e-Lung computed tomography biomarkers are associated with outcomes in fibrotic interstitial lung diseases

The e-Lung weighted reticulovascular score (WRVS) is an automated CT biomarker that quantifies interstitial lung disease (ILD) severity and is associated with prognosis in patients with idiopathic pulmonary fibrosis (IPF). Aim: To evaluate WRVS as a prognostic factor in patients with non-IPF fibrotic ILD (fILD).

Conclusion: In patients with non-IPF fILD, the e-Lung WRVS biomarker is associated with mortality and FVC decline when applied to baseline HRCT scans replicating previous studies in IPF. Patients with an increase in WRVS of 3% on serial CT scans have significantly increased risk of mortality.