The e-STROKE Study: The Design of a Prospective Observational Multicentral Study

Introduction: The e-STROKE study is a prospective, multicenter observational study designed to assess the impact of various CT parameters (including e-ASPECT, CT perfusion (CTP), collateral flow status, and the size and location of the ischemic lesion) on the clinical outcomes of patients with ischemic stroke, as evaluated by the modified Rankin Scale (mRS) three months post-stroke. It also aims to investigate whether the use of multimodal CT imaging increases the number of patients eligible for recanalization therapy.

Aims: The primary aim is to determine the predictive value of CT parameters (e-ASPECTS, CTP, collateral vessel status, and ischemic lesion volume and location) on three-month functional outcomes in patients with non-lacunar stroke following recanalization treatment (IVT and/or MT). The secondary aim is to evaluate whether multimodal CT examination increases the number of patients eligible for recanalization therapy.

Methods: This multicenter observational study involves patients with suspected acute ischemic stroke and a premorbid mRS ≤ 4, treated with EVT, IVT, or managed conservatively in stroke centers within the Czech Stroke Research Network (STROCZECH). Data collection integrates the RES-Q registry and radiological data from the e-STROKE system provided by Brainomix Ltd.

Conclusions: We anticipate collecting robust clinical and radiological data from approximately 2000 patients across 22 centers over a 12-month period. The results are expected to enhance the precision of diagnostic and prognostic radiological markers in managing acute stroke.