This review of prehospital stroke treatment and the data emanating from mobile stroke unit (MSU) studies shows that diagnostic clarification in the ambulance allows not only prehospital thrombolysis, comprehensive pre-notification, and correct triage to the most appropriate target hospital, but novel options that might also include cause-specific adjustment of physiological parameters, reversal of anticoagulant effects, and prehospital management of other cerebral emergencies.